Menu

RINA Serie BIOTECH
High Performance Centrifuge

Description

BiotechIndustry faces new challenges and has become a pharmaindustry pillar.

The use of state-of-the-art materials and tool machinery, reliability of automation devices, new technical means (software simulations...) and cutting-edge techniques for Research and Development, mixed with our collaboration with customers, leads totaylor-made applications completely adapted to the most demanding requests within biotechnology and fine chemicals industries.

The RINA BIOtech centrifuges are conceived upon the "all in one" concept, allowing several operations within the same equipment without any need of intermediary handling by the operator, while ensuring the hygiene, traceability and repeatability of the loop, keeping away the risk of crossed contamination, either for the process or the staff.

Observing the most straight norms for GMP since the very first steps of the manufacturing of the RINA Biotech, obliges to consider every single technical detail:

  • Accessibility to any part of the equipment for an easy cleaning and no blind spots.
  • Special polishing (electropolishing, mechanical...)
  • CIP (Cleaning in Place) systems, with Riboflavin test validation.
  • SIP (Sterilization in Place) systems, following the most strict requests for biochemical and biological environments, vacuum conditions, heating and cooling.
  • Automation systems observing the CFR 21, part 11 or GAM P4 norms.
  • Tightness test for pressurized equipment.
  • Filter integrity tests.

Applications

Among the most developed fields of application within the pharmaceutical environment, as oncology, hematology, homeopathy... the use of biological raw materials (animal cells, micro plants, natural derivate...) is becoming an standard for getting to the active principle ingredient. Also, new ways of vectoring such API towards its target: micro encapsulation, micro-spheres, new serum basis...

Several incoming processes are now used for the cutting-edge pharmaceutical production (biotechnology) requesting equipments and devices fitting their particular characteristics: fermentation, micro bodies fractioning, nanoparticules treatments... All them searching for adding value to the processed products, researches of new developments.

These are some examples where RINA BIOtech has helped our customers to create value.

  • Serum extraction/purification
  • Vaccines preparations
  • Amino acids treatment
  • Enzymes treatment
  • Treatment of bacteriological culture cells
  • Protein separation
  • Plasma fractionning
  • Blood fractioning
  • API microencapsulation
  • Etc…

RINA BIOTECH

Centrifuges RINA SERIES BIOTECH responds to current and more advanced requirements of the Biotechnology industry.

On the basis of reliable mechanical standard centrifuges NADEU RIERA, SA

Equipment that enable process as the most sophisticated requirements:

  • Separation of products from fermentation
  • Concept of multi-step equipment within the centrifuge itself
  • Processes all kinds of guarantees:
 
  • traceability
  • certified cleaning
  • certified sterilization
  • Compliance with the strictest standards GMP / GAMP
  • The best mechanical performance of the market.

In any case, the developments are as RINABiotech units (Taylor-made) and Customer Process.

Operation

The RINA BIOtech centrifuges are taylor-made machines, integrating every single particularity of the requested process to be made in it. Even so, all RINA BIOtech share its aseptic-focus design, observing the GMP for ultra clean environments, according to any EHDG and FDA recommendation.

Usually, the RINA BIOtechcentfrifuge consist of a decanter centrifuge application applying high g effect separation (around 8.000g), allowing different operations along the full process cycle: extraction, purification, pH modification, resuspension...

The "All in One" concept enables the capacity of including different steps and operations in one unique machine depending on the need of the process, controlling: temperature (heating, cooling), pressure (overpressure, vacuum), pH, stirring ...

Images

Technical Specifications

Type

Basket
Ø
mm
Basket Height
mm
Cake thickness
mm
Basket capacity
dm3
Bulk density
Kg/m3
Nominal load
Kg
Decanting surface
dm2
Speed
rpm
Centrif.
Factor
(g)
Basket wall SIGMA
m2
Dry weight
Kg
Overall dimensions
mm
300D250x150 250 150 35 3,5 1250 4 11,78 5400 4000 360    
300D400x200 400 200 60 12 1250 15 25,13 4250 4000 754    
300D600x300 600 300 90 40 1250 50 56,55 3465 4000 2263    
300D600x350 600 350 90 50 1250 60 65,97 3465 4000 2640    
300D800x400 800 400 120 100 1000 1000 100,53 3000 4000 4021    
300D1000x500 1000 500 150 200 1250 250 157,08 2685 4000 10066    

Construction Materials

The RINA Biotech centrifuges are built of materials compatible with the product to be processed, and will vary according to the requirements as for temperature, wearing, mechanical- and chemical resistance and other particular specifications.

316L stainless steel DIN 1.4404
316 Ti stainless stell DIN 1.4571
904L stainless steel (Uranus B6, 2RK65) DIN 1.4539
DUPLEX DIN 1.4462
HASTELLOY C-22 DIN 2.4602
HASTELLOY C-276 DIN 2.4819
Others

Linings (whenneeded):

Halar
PTFE
Ebonite
Others

Standards

The RINA 300 centrifuges comply with the most exigent design and quality criteria, and can be used in any industry and process. The particular features of every installation will suit to the specific application for which it has been manufactured, and will vary in function of the devices incorporated.

In any case, they meet or may meet upon requirement, the following standards:

 

 
ce EN-ISO 13849-1   ok Always according to the PL required
EMC   ok Always
SIL 2 sil ok Subject to the risk level
EN/IEC-62061
SIL 3 sil ok Subject to the risk level
EN/IEC-62061
CE-ATEX 94/9/EC ex ok When required
GMP compliance   gmp ok Always

FDA

21 CFR part 11
  fda ok Validation feasible
Blanketing/Inertization   blanketing ok When required
Automatic discharge     ok Always
Batch/Continuous   , Batch/continuas  
Heating/cooling   heating / cooling ok When required
Pressure/vacuum     ok When required
CIP   cip ok When required
SIP   sterile ok When required
EHEDG compliance   ehedg ok  
ul     ok Subject to the market area
gost     ok Subject to the market area
Fundations     Not required Self-supported
Plug & play concept   plug&play ok Always

 

 

dryer

RIERA NADEU, S.A.
Tel: (+34) 93 840 70 72
Email: comercial@rieranadeu.com
Polígono Industrial Coll de la Manya
Cal Ros dels Ocells, 1-3, Parcela 8, Nave 1 y 2
08403 Granollers Barcelona (SPAIN)

© Copyright RIERA NADEU, S.A. 2013